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Postgraduate School of Life Sciences

 
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Current Studentships in the Wellcome Trust/Cancer Research UK Gurdon Institute, Department of Biochemistry, Department of Genetics, Department of Pathology, Department of Pharmacology, Department of Plant Sciences, Department of Zoology, Department of Veterinary Medicine, C.I.M.R. Clinical Biochemistry or the C.I.M.R. Haematology at the University of Cambridge.
Updated: 36 min 7 sec ago

Senior Clinical Training Scholar (SCTS) in Small Animal Cardiology

Mon, 22/04/2024 - 00:00

SCHOLARSHIP AWARD: £27,820.00

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years.

The Scholarship provides an outstanding opportunity to receive specialist training in all aspects of small animal cardiology and is available to start from December 2024.

You will receive core training in all aspects of clinical cardiology, including interventional procedures and transoesophageal echocardiography. You will also be required to undertake and publish a research project. The training programme is approved by the European College of Veterinary Internal Medicine (ECVIM-CA).

The Scholar will be required to register for the Diploma of the European College of Veterinary Internal Medicine. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion practice, in addition to small-group teaching of veterinary students.

You must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying you for membership. Membership will be required prior to commencing the Scholarship. Completion of an appropriate internship or a minimum of two years' experience in small animal practice is essential.

The internship has an abundance of benefits such as:

  • Tax-free stipend

  • Academic opportunities, e.g. teach Cambridge students during rotations and College supervision opportunities; weekly Department research and clinical seminars; journal and book clubs

  • Generous CPD allowance

For more information on benefits and our internship programmes: https://www.hospital.vet.cam.ac.uk/qvsh/internship-and-residency-programmes

Informal enquiries should be directed to Jose Novo Matos (Principal Clinical Cardiologist) by email: jms330@cam.ac.uk

Interviews will be held on Wednesday, 5th of June 2024.

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Applications will be monitored regularly, and we may contact candidates prior to the closing date. We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible.

Please quote reference PP41325 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

JCTS in Small Animal Studies x 6

Fri, 22/03/2024 - 00:00

Scholarship Award: £18,370.00 per annum including accommodation

Applications are invited for this one-year post-graduate training programme based in the Queen's Veterinary School Small Animal Hospital. Junior Clinical Training Scholars will receive training and tuition as they rotate through anaesthesia, cardiology, diagnostic imaging, orthopaedics, dermatology, ophthalmology, internal medicine, neurology, oncology, clinical pathology and soft tissue surgery and be supervised by recognised specialists in each field. Scholars will also have responsibility for primary care cases seen at the hospital's charity clinics, and be involved in supervision and guidance of final year veterinary students. Scholars will be an integral part of the out of hours care of animals within the hospital, especially within the intensive care unit. Candidates must be Members of the Royal College of Veterinary Surgeons (RCVS) and should have the following skills and experience:

  • Experience in neutering and performing dental work in dogs and cats

    • Completion of 1 year in primary care veterinary practice in the UK by the start of the scholarship

For applicants for whom English is not their first language, a score of 7.5 in IELTS (with no element under 7), or a score of 100 in TOEFL (with no element less than 24) is desirable.

A JCTS Application Form (JCTS 1) and Information Pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed Junior Clinical Training Scholarship Application Form (JCTS 1), a CV and Covering Letter giving reasons for wishing to undertake the JCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Informal enquiries should be directed to the Internship Directors, by email: internship.enquiries@vet.cam.ac.uk.

Please quote reference PP39786 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. Please note: The ability to take up this Scholarship is contingent upon you being able to evidence your right to work in the UK, or through gaining the right to work via the UK immigration system. Evidence will need to be provided before an offer can be made. Regrettably, this Scholarship is not suitable for sponsorship via the Skilled Worker or Temporary Worker visa routes as the minimum requirements cannot be met.

Candidates may be contacted for interview prior to the closing date.

We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible.

Senior Clinical Training Scholarship (SCTS) in Diagnostic Imaging

Fri, 22/03/2024 - 00:00

Scholarship award: £27,820.00

This Senior Clinical Training Scholarship (SCTS) provides an outstanding opportunity to study for a postgraduate qualification, and is available to start on 1 July 2024 or as soon as possible thereafter. You will be trained in all aspects of veterinary diagnostic imaging, including radiology, ultrasonography, magnetic resonance imaging and computed tomography. The training programme is approved by the European College of Veterinary Diagnostic Imaging.

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years. It is subject to an initial monitoring period of six months and review on an annual basis.

You will be required to register with the ECVDI for the Diploma in Diagnostic Imaging. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion clinic, in addition to small-group teaching of veterinary students. You will also be expected to participate in research projects as part of your training.

You must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying you for membership. Completion of a recognised internship or a minimum of two years' experience in small animal practice is essential.

We welcome candidates wishing to apply for the scholarship to come and visit the hospital and to meet the team. Please contact Marie-Aude Genain, Principal Clinical Radiologist, on mag72@cam.ac.uk to arrange a convenient date.

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Closing date for applications: Wednesday 17 April 2024

Interviews will be held on the week commencing 22 April 2024.

Please quote reference PP41012 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship- Uncovering the chemical origin of lipid membrane diversity (3.5 years F

Thu, 29/02/2024 - 00:00

A fully funded 3.5-year PhD studentship, supported by an LCLU Joint Collaborative Programme grant, is available in the ProtocellLab (www.bonfiolab.eu) at the Department of Biochemistry commencing on 1 October 2024.

Summary:The origin of cell membranes is a major unresolved issue in evolution. Evolutionary biology points to the existence of primitive cells with compositionally diverse membranes. However, the assumption that such lipid diversity is dependent upon enzymatic chemistry has generated models comprising compositionally minimal membranes (binary or ternary mixtures of short-chain fatty or phosphatidic acids). This project aims to reconcile biology and chemistry by challenging the critical limiting assumption that lipid diversity cannot be achieved through non-enzymatic chemistries. The project will lead to a fundamental understanding of the origins of lipid diversity, including the features now associated with bacterial and archaeal lipids; new strategies based on compositionally diverse membranes to probe, sense or replicate cellular behaviours; and a deep-rooted understanding of the emergence and evolution of cellular processes at the molecular level.

Background: While prebiotic pathways to all four RNA nucleotides and most of the twenty biological amino acids have been proposed, only a few non-enzymatic routes to modern lipids have been described. As such, prebiotic chemistry has yet to address models of primitive membranes comprising the vast structural diversity of modern lipids. However, if lipid diversity is an essential feature of modern membranes, can non-enzymatic chemistry be harnessed to generate lipid diversity?

Approach: To identify the set of diverse lipids that could have been formed non-enzymatically on early Earth, the student will adapt diversity-oriented synthetic strategies to prebiotic chemistry by transforming primitive lipids into modern lipids through non-enzymatic chemical strategies. The student will design and develop novel synthetic methods to generate libraries of lipids using a combination of solution-phase, membrane-templated and dry-state chemistries. The supramolecular properties of synthetic lipids and their biophysical features will be evaluated by fluorescence spectroscopy, dynamic light scattering, and light and electron microscopy. Additionally, encapsulated prebiotic reactions, such as RNA replication and protometabolic processes, will be investigated to better understand the chemistry of bioinspired systems.

ProtocellLab: The main focus of the ProtocellLab is to understand how primitive cells emerged on early Earth and how they started to interact with one another. The group is moving to the Department of Biochemistry in June 2024. The PhD student will develop skills in the areas of prebiotic, systems and supramolecular chemistry, applied to primitive and artificial cells. The small group size (5 PhD students and 2 PDRAs) ensures close supervision and training. The project offers interactions with other groups within the Leverhulme Centre for Life in the Universe, with the possibility of performing research periods abroad.

Fixed-term: The funds for this post are available for 3.5 years in the first instance.

Application. To apply, please e-mail Dr Claudia Bonfio (cb2036@cam.ac.uk) with the following information by 29 March 2024:

  • CV (max two pages), with full contact details of 2 academic referees.
  • Motivation letter (max two pages) highlighting (a) your research interests, (b) what you hope to achieve from the programme, and (c) why you wish to undertake this PhD.

Please note that applicants are also required to officially apply to the University using the Applicant Portal: http://www.graduate.study.cam.ac.uk/how-do-i-apply by the deadline of 29 March 2024. Please search in the Course Directory for 'Biochemistry' PhD (Course Code: BLBI22) as the programme of study. Applicants should indicate on the application form that they wish to apply for other sources of funding.

Any questions regarding the application process should be directed to the Postgraduate Admissions Administrator at pg-entry@bioc.cam.ac.uk.

This studentship is open to UK citizens or UK nationals or have a settled/pre-settled status only.

Please quote reference PH40713 on your application and in any correspondence about this vacancy.

The Protocell Lab and the University actively support equality, diversity and inclusion and encourage applications from all sections of society. We place major emphasis on the importance of teamwork and an enjoyable work environment as a foundation for performing internationally leading research. This will allow the student to acquire cutting-edge research methodologies in a supportive environment where they can focus on making the best possible scientific progress.

Senior Clinical Training Scholar in Small Animal Medicine

Tue, 20/02/2024 - 00:00

Scholarship award: £27,820.00 (Subject to change)

The Senior Clinical Training Scholarship in Small Animal Medicine is available, to start on 1 July 2024. The training programme covers all aspects of small animal medicine, including cardiology, oncology, medical neurology, diagnostic imaging and clinical pathology, and is approved by the European College of Veterinary Internal Medicine.

The Scholar will be required to register for the Diploma of the European College of Veterinary Internal Medicine. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion practice, in addition to small-group teaching of veterinary students.

An applicant must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying her/him for membership. Completion of an appropriate internship or a minimum of two years' experience in small animal practice is essential.

Informal enquiries should be directed to Nick Bexfield, Clinical Director of Small Animal Services, by email: nb289@cam.ac.uk

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake this SCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@vet.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Closing date for applications: Midnight on Tuesday, 19 March 2024

Please quote reference PP40591 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

3-year PhD studentship (Fixed Term)

Wed, 31/01/2024 - 00:00

Applications are invited for a fully-funded 3-year studentship based in the Department of Pathology at the University of Cambridge under the supervision of Prof Nicholas Coleman and Dr Anton Enright.

**Project title: Investigating Alternative Splicing As A Driver Mechanism And Therapeutic Target In Squamous Cell Carcinoma**

Squamous cell carcinomas (SCCs) are common malignancies that arise at sites including the skin, aero-digestive tract and genitourinary tract. Despite different SCCs being associated with at least one carcinogenic insult (e.g. tobacco, human papillomavirus infection and UV damage), the drivers of SCC carcinogenesis remain largely elusive. Our lab is testing the hypothesis that aberrant RNA splicing is a central mechanism of carcinogenesis in SCCs. We have recently shown that splicing dysregulation in SCCs is not a passenger phenomenon, but likely constitutes a critical driver of oncogenesis, reflected by splicing aberrations in hallmark-related genes across SCC subtypes and a difference in splicing regulation compared with healthy tissues and other tumour types.

This studentship will allow us to advance our understanding of how splicing contributes to oncogenesis in SCC and whether it is a vulnerability that can be targeted therapeutically. Our objectives will be:

  1. Build an atlas of alternative splicing in SCC, using, single-cell RNA sequencing, bulk deep transcriptional profiling and bulk whole genome sequencing. All data will be processed using our bespoke splice-aware RNA-Seq pipelines. The datasets will be examined to characterize subtype-specific and cross-subtype splicing signatures, as well as signatures linked to known causative environmental factors, such as UV damage or human papillomavirus infection.

  2. Understand the co-evolution of aberrant splicing and progression of HPV16-associated SCC, using the unique cell line model W12.

  3. Characterise the role of the splicing factor serine/arginine-rich splicing factor 10 (SRSF10) in regulating oncogenic splicing in SCC, by tracking splicing changes following depletion of SRSF10 in SCC vs. adenocarcinoma and non-malignant cell lines.

Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.

This is a three year PhD studentship, funded by The Pathological Society of Great Britain and Ireland. It involves a combination of computational and wet lab research.

Applicants should hold (or expect to obtain) the equivalent of a UK 2.1 or higher in an undergraduate honours or Masters degree in a relevant subject such as molecular biology, genetics or computational biology. The studentship is open to those eligible for the Home rate of University fees. Applications should include academic transcripts, CV, statement of purpose and two references.

If you have any queries regarding the application process please contact postgrad@path.cam.ac.uk

Please quote reference PK40360 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

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