Latest Research in Cambridge

A pivotal clinical trial of a 'pill-on-a-thread' test, which will decide if it becomes a new screening programme for oesophageal cancer, has welcomed its first participants.

The Human Cell Atlas is an ambitious project to map every cell in the human body. Its co-lead, Professor Sarah Teichmann, explains how the initiative is already changing our understanding of our bodies.

Researchers have developed a mindfulness therapy tailored specifically to appeal to teenagers to help them cope with increasing levels of depression and mental health problems.

Scientists say the findings might shed light on the link between loneliness and mental health conditions such as anxiety disorders, which are on the rise in young people.

Data also suggests that Democrat appeals to unity were popular across the board, but “politicians need to do more to understand why some people feel under threat”. 

A drug commonly used to treat glaucoma has been shown in zebrafish and mice to protect against the build-up in the brain of the protein tau, which causes various forms of dementia and is implicated in Alzheimer’s disease.

Researchers have developed a machine learning algorithm to accurately detect heart murmurs in dogs, one of the main indicators of cardiac disease, which affects a large proportion of some smaller breeds such as King Charles Spaniels.

A type of therapy that involves applying a magnetic field to both sides of the brain has been shown to be effective at rapidly treating depression in patients for whom standard treatments have been ineffective.

10 Cambridge spinouts on putting their research into practice to improve outcomes for cancer patients - and why Cambridge is a great place to do this.    

A team from across the Cambridge life sciences, technology and business worlds has announced a multi-million-pound, three-year collaboration with the Advanced Research and Invention Agency (ARIA), the UK government’s new research funding agency.

Damage to the brainstem – the brain’s ‘control centre’ – is behind long-lasting physical and psychiatric effects of severe Covid-19 infection, a study suggests.

A new Cambridge network is turning to basic science in a bid to advance our understanding and treatment of mental health disorders

The first wiring diagram of every neuron in an adult brain and the 50 million connections between them has been produced for a fruit fly.

While divisive social media posts get more traction in countries such as the US, a new study shows that celebrating national unity is the way to go viral in Ukraine.

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LinkedInTwitterFacebook Combining kidney and lung cancer screening helps identify tumours before symptoms develop

By Craig Brierley

Combining screening for lung and kidney cancers – for both of which smoking is a risk factor – could help identify undiagnosed cases of kidney cancer, say researchers as they release the results from a study showing this approach is feasible and acceptable to participants.

Early detection of cancer allows the best chance of cure using effective treatments such as surgery. The UK has recently approved a screening programme for smokers at greatest risk of lung cancer. The programme makes use of lung computed tomography (CT) scans, which build up a detailed picture of the inside of an individual’s body by taking multiple x-rays.

Certain cancers, however, are relatively rare and standalone screening programmes are unlikely to be cost-effective. One such disease is kidney cancer. Kidney cancer is the ninth commonest cancer in men and 14th in women, and is largely curable if treated at an early stage. But almost nine in ten patients (87%) will have no symptoms at the stage when it is still curable.

As lung and kidney cancers share risk factors, Yorkshire Cancer Research, in partnership with experts at the University of Cambridge, established the Yorkshire Kidney Screening Trial to see whether screening for kidney cancer could take place at the same time as screening for lung cancer. The results are published in European Urology.

“Kidney cancer is curable if we catch it early enough, but it’s a largely silent disease at that stage, making it very difficult to spot."

Professor Grant Stewart, University of Cambridge, Chief Investigator on the trial

"We know that smokers who are at high risk of lung cancer are also at increased risk of kidney cancer, so it makes sense to see if we can look for both conditions at the same time.”

Abdominal CT scans were offered to 4,019 ‘ever-smokers’ – that is, people who had smoked at some period in their life – aged 55-80 years old who were attending a lung cancer screening trial between May 2021-October 2022.

Of those offered the additional abdominal scan, more than nine in 10 (93%) accepted. Of these, almost two-thirds (64%) were found to have normal abdominal scans. One in five (20%) required an imaging review but no further action. 15% required further investigations at a clinical review.

One in twenty (5.3%) participants had a previously-undetected serious finding only seen on the abdominal CT scans, including kidney and other abdominal cancers, abdominal aortic aneurysms (a swelling in the artery that carries blood from the heart to the abdomen, which can be serious because they risk bursting) and kidney stones.

Professor Stewart added: “We were able to make use of an existing targeted screening study to ‘bolt-on’ an additional screening test. Patients were very receptive to be screened for several conditions, and this approach helped us identify serious findings in one in 20 participants that carried a real prospect of seriously threatening life span, or of having a substantial impact on their lives.”

A concern with any screening programme is the identification of incidental, non-serious lesions that do not require treatment but carry the risks associated with diagnosis and treatment, create unnecessary anxiety for these individuals, and potentially divert healthcare resources away from other conditions.

In the Yorkshire Kidney Screening Trial, a quarter of participants (25%) had non-serious findings. However, because the trials was set up to allow a robust clinical review of the radiological findings and clear lines of communication with associated specialities to determine if further tests or clinics were needed, only a third of these (8.5% of participants) had incidental findings that triggered further action in the form of further clinic appointments or investigations.

A sub-study published separately also showed that those with non-serious findings did not have lasting psychological, social or financial harms.

Speaking on behalf of the trial funder, Dr Stuart Griffiths, Director of Research at Yorkshire Cancer Research said: “People with kidney cancer are often diagnosed at a late stage when treatment options are more limited. Screening people before they experience any symptoms means the kidney cancer can be found at a very early stage – enabling many people to receive life-saving treatment."

"Adding an abdominal CT to the recently approved lung cancer screening programme provides a vital opportunity to improve early diagnosis and save thousands of lives in Yorkshire and across the UK.”

Dr Stuart Griffiths, Director of Research, Yorkshire Cancer Research

“When they said, ‘You’ve got the C’, I thought, ‘It is what it is. There’s no point worrying.’”

Jenifer Perrin

Jenifer Perrin

Jenifer Perrin, aged 81, has lived in Otley on the outskirts of Leeds for 50 years. She used to be a sewing machinist at a local factory, where she worked making curtains – a skill she says macular degeneration has sadly put paid to.

In 2019, Mrs Perrin was invited for a CT scan as part of the Yorkshire Lung Screening Trial (YLST) in a mobile unit, which fortunately found no sign of disease. In October 2022, after a follow-up scan as part of YLST, she was offered a kidney screening as part of the Yorkshire Kidney Screening Trial. She had never been ill and had no symptoms, but agreed. This time, however, the scan picked up an abnormality, a small tumour, around 2.5cm in diameter.

“When they said, ‘You’ve got the C’, I just took a deep breath,” she says. “I thought, ‘Well, it is what it is. There’s no point worrying.’”

Following a biopsy to confirm that the tumour was indeed cancerous, Mrs Perrin was referred to Professor Tze Min Wah and offered treatment using high intensity focused ultrasound (HIFU), a minimally-invasive treatment that required her to go under a general anaesthetic, but involved “no needles and no cutting,” she says.

The operation took place on the Thursday before the Coronation of King Charles III and apart from sickness that she puts down to the after-effects of the anaesthetic, she says there were no side-effects.

Following the treatment, she would return to St James’s Hospital every month for a follow-up scan and blood test. In October 2023, she was finally given the all clear.

“I’m really glad I had the chance to take part in the trial,” she says. “I’d never been ill, so without the CT scan, they might not have spotted my cancer early. As it was, they were able to blast it away using ultrasound. I think I was the second person in the world to have this treatment – the first woman in the world to get it. I like telling people that!”

The Yorkshire Kidney Screening Trial was funded by Yorkshire Cancer Research. Additional support was provided by the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre and Manchester Biomedical Research Centre,  and by Kidney Cancer UK.

References
Stewart, GD et al. Abdominal Noncontrast Computed Tomography Scanning to Screen for Kidney Cancer and Other Abdominal Pathology Within Community-based Computed Tomography Screening for Lung Cancer: Results of the Yorkshire Kidney Screening Trial. European Urology; 12 Sept 2024; DOI: 10.1016/j.eururo.2024.08.029

Usher-Smith, JA et al. Short-term psychosocial outcomes of adding a non-contrast abdominal computed tomography (CT) scan to the thoracic CT within lung cancer screening. BJUI; 14 Dec 2023; DOI: 10.1111/bju.16260

Usher-Smith, JA et al. Acceptability of adding a non-contrast abdominal CT scan to screen for kidney cancer and other abdominal pathology within a community-based CT screening programme for lung cancer: A qualitative study. PLOS ONE; 1 Jul 2024; DOI: 10.1371/journal.pone.0300313

Main image
Kidney cancer illustration (SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY)

The text in this work is licensed under a Creative Commons Attribution 4.0 International License

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We will find cancer earlier and treat it better. Join us. Donate now TopBuilt with Shorthand { setTimeout(() => { document.querySelectorAll("#main a").forEach(link => link.classList.remove("campl-external")); }, 2050); }); //--> Summary: 

Combining screening for lung and kidney cancers could help identify undiagnosed cases of kidney cancer, say researchers as they release the results from a study showing this approach is feasible and acceptable to participants.

Image: Affiliation (schools and institutions): School of Clinical MedicineCancer Research UK Cambridge CentreExternal Affiliations: Yorkshire Cancer ResearchPeople (our academics and staff): Grant StewartSubject (including Spotlight on ... where applicable): CancerSection: ResearchNews type: NewsSuper Tags: Health and medicineShorthand Story Description/Subtitle: Combining screening for lung and kidney cancers could help identify undiagnosed cases of kidney cancer, say researchers as they release the results from a study showing this approach is feasible and acceptable to participants.Shorthand Story Authors: Craig BrierleyShorthand Story Thumbnail: https://www.cam.ac.uk/sites/www.cam.ac.uk/files/shorthand/247881/IsdcO20ijM/assets/jO50plON35/gettyimages-1607097077-land-thumbnail.jpg

Alcohol consumption is the fifth largest contributor to premature death and disease worldwide. In 2016 it was estimated to have caused approximately 3 million deaths worldwide.

Professor Dame Theresa Marteau and colleagues at the Behaviour and Health Research Unit have shown previously that serving wine in smaller glasses is associated with a decrease in sales.

To see if this effect was seen with other alcoholic drinks, they approached venues in England and asked them to remove the pint serving size and instead offer two-thirds as the largest option for four weeks, with four-week non-intervention periods before and after as a comparison.

In a study published in PLOS Medicine, the team found that removing the pint reduced the daily mean volume of beer, lager and cider sold by 9.7%, although there was a slight increase in the amount of wine purchased, with one pub contributing to half of the increase of wine sales. They report that although customers did not complain, fewer than 1% of venues approached agreed to participate and the intervention involved only 12 establishments.

Professor Marteau said: “Alcohol harms our health, increasing the risk of injury and many diseases including heart disease, bowel, breast and liver cancers. While we may all enjoy a drink, the less we drink the better our health.

“As we’ve shown is the case with wine, removing the largest serving size for beer, lager and cider – in this case, the pint – could encourage people to drink less. This could be beneficial both to the nation’s health and the health of individuals.”

Further assessment is needed, particularly into whether people fully compensated for reduced beer consumption by drinking other alcoholic drinks, but the intervention merits consideration for inclusion in alcohol control policies. Smaller serving sizes could contribute towards reducing alcohol consumption across populations and thereby decrease the risk of seven cancers and other diseases.

Reference
Mantzari, E et al. Impact on beer sales of removing the pint serving size: An A-B-A reversal trial in pubs, bars, and restaurants in England. PLOS Medicine; 17 Sept 2024; DOI: 10.1371/journal.pmed.1004442

Adapted from a press release by PLOS Medicine

Cambridge researchers have shown that reducing the serving size for beer, lager and cider reduces the volume of those drinks consumed in pubs, bars and restaurants, which could have wider public health benefits.

Public healthalcoholTheresa MarteauSchool of Clinical MedicineDepartment of Public Health and Primary CareBehaviour and Health Research Unit (BHRU)Cambridge Public HealthWhile we may all enjoy a drink, the less we drink the better our healthTheresa MarteauELEVATE (Pexels)Barman handing a customer a pint of beer

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

YesLicence type: Public DomainNews type: NewsSuper Tags: Health and medicine

A team lead by researchers at the University of Cambridge has developed a monoclonal antibody drug, using a technique involving genetically engineered mice, that may help prevent infection from Acinetobacter baumannii, a bacteria associated with hospital-acquired infections, which is particularly common in Asia.

A. baumannii bacteria can cause life-threatening respiratory illness and sepsis in vulnerable individuals, particularly in newborn babies whose immune systems have not fully developed. It is usually spread through contaminated surfaces, medical equipment and via contact with others. In recent years infections with strains of this bacteria that are resistant to almost every antibiotic available have become common.

Professor Stephen Baker from the Cambridge Institute of Therapeutic Immunology and Infectious Disease at the University of Cambridge said “A. baumannii is good at sticking to medical equipment, and if people are vulnerable or don't have a particularly well-developed immune system, they can succumb to this infection and get aggressive pneumonia requiring ventilation – and in many cases, the patients can acquire the infection from the ventilation itself.

“The bacteria are naturally resistant to many antimicrobials, but as they’re now found in hospitals, they’ve acquired resistance to almost everything we can use. In some hospitals in Asia, where the infections are most common, there isn't a single antibiotic that will work against them. They’ve become impossible to treat.”

In a study published today in Nature Communications, the team produced monoclonal antibodies using transgenic mice – mice that have been genetically-engineered to have a human-like immune system, producing human antibodies instead of mouse antibodies. They went on to show that these monoclonal antibodies were able prevent infection with A. baumannii derived from clinical samples.

Monoclonal antibodies are a growing area of medicine, commonly used to treat conditions including cancer (for example, Herceptin for treating some breast cancers) and autoimmune disease (for example, Humira for treating rheumatoid arthritis, psoriasis, Crohn's disease, and ulcerative colitis).

Usually, monoclonal antibodies are developed from the antibodies of patients who have recovered from an infection, or they are designed to recognise and target a particular antigen. For example, monoclonal antibodies targeting the ‘spike protein’ of the SARS-CoV-2 coronavirus were explored as a way of treating COVID-19.

In the approach taken by the Cambridge team, however, transgenic mice were exposed to the outer membrane of A. baumannii bacteria, triggering an immune response. The researchers then isolated almost 300 different antibodies and tested which of these was the most effective at recognising live bacteria, identifying the single monoclonal antibody mAb1416 as the best.

Professor Baker said: “Using this method, we don't infect the mice with the live bacteria, but we instead immunise them using multiple different elements and let the mouse’s immune system work out which ones to develop antibodies against. Because these mice have ‘humanised’ immune systems, we wouldn’t then need to reengineer the antibodies to work in humans.”

The team treated mice with mAb1416, and 24 hours later exposed them to A. baumannii isolated from a child with sepsis in an intensive care unit. They found that those mice treated with the drug saw a significant reduction in bacterial load in their lungs a further 24 hours later, compared to mice that were not treated.

All of the isolates used to produce and test the monoclonal antibodies were from patients in Ho Chi Minh City, Vietnam, but the isolate used to test mAb1416 was taken from a patient ten years later than the other isolates. This is important because it shows that mAb1416 was protective against A. baumannii bacteria that may have evolved over time.

Professor Baker said: “Using this technique, you can take any bacterial antigen or cocktail of antigens, rather than waiting for somebody that's recovered from a particular infection – who you assume has developed an appropriate antibody response – give it to the mice and extract the antibodies you think are the most important.”

More work is now needed to understand the mechanism by which mAb1416 protects against infection, as this could allow the team to develop an even more effective treatment. Any potential new drug will then need to be tested in safety trials in animals before being trialled in patients.

Professor Baker added: “We know that monoclonal antibodies are safe and that they work, and the technology exists to produce them – what we have done is identify how to hit bacteria with them. Apart from the cost effectiveness, there's no reason why this couldn’t become a medicine within a few years. Given the emergency presented by antimicrobial resistance, this could become a powerful new weapon to fight back.”

The research was funded by the Bill & Melinda Gates Foundation, the UK Medical Research Council Newton Fund, the Viet Nam Ministry of Science and Technology, and Wellcome.

Professor Baker is a fellow at Wolfson College, Cambridge.

Reference
Baker, S, Krishna, A & Higham, S. Exploiting human immune repertoire transgenic mice to identify protective monoclonal antibodies against an extensively antimicrobial resistant nosocomial bacterial pathogen. Nat Comms; 12 Sept 2024; DOI: 10.1038/s41467-024-52357-8

Monoclonal antibodies – treatments developed by cloning a cell that makes an antibody – could help provide an answer to the growing problem of antimicrobial resistance, say scientists.

Infectious diseasesantimicrobial resistance (AMR)animal researchStephen BakerBill and Melinda Gates FoundationMedical Research CouncilVietNam Ministry of Science and TechnologyWellcomeSchool of Clinical MedicineDepartment of MedicineCambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID)Wolfson CollegeWe know that monoclonal antibodies are safe and that they work, and the technology exists to produce them – what we have done is identify how to hit bacteria with themStephen BakerTopMicrobialStock (Getty Images)A Petri dish with a culture of the Superbug Acinetobacter baumannii next to antibiotics

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

YesNews type: NewsSuper Tags: Health and medicine

The study, by researchers at the University of Cambridge’s Sainsbury Laboratory, also found that bees prefer larger bullseyes over small ones, and fly 25% faster between artificial flower discs with larger bullseyes – potentially boosting efficiency for both bees and blossoms.

Using the hibiscus plant as a model, the researchers selected plants with three differently sized bullseye patterns – H. richardsonii (small bullseye covering 4% of flower disc), H. trionum (medium bullseye covering 16%) and a transgenic line (mutation) of H. trionum (large bullseye covering 36%).

They found that petal pre-patterning is established very early in the flower’s formation long before the petal shows any visible colour. The petal acts like a 'paint-by-numbers' canvas, where different regions are predetermined to develop specific colours and textures long before they start looking different from one another.

The research also shows plants can precisely control and modify the shape and size of these patterns using multiple mechanisms, highlighting the evolutionary importance of the process. By fine-tuning these designs, plants may gain a competitive advantage in the contest to attract pollinators.

The findings are published today in the journal Science Advances.

Dr Edwige Moyroud, who leads a research team studying the mechanisms underlying pattern formation in petals, explained: “If a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of tools. By studying how bullseye patterns change, what we are really trying to understand is how nature generates biodiversity.”

In the small hibiscus species Hibiscus trionum, a striking bullseye pattern is formed on the petals, featuring a dark purple centre surrounded by white.

Lead author Dr Lucie Riglet investigated the mechanism behind hibiscus petal patterning by analysing petal development in three hibiscus flowers that had the same total size but different bullseye sizes – small, medium and large.

She found that the pre-pattern begins as a small, crescent-shaped region long before the bullseye is visible on tiny petals less than 0.2mm in size.

Dr Riglet said: “At the earliest stage we could dissect, the petals have around 700 cells and are still greenish in colour, with no visible purple pigment and no difference in cell shape or size. When the petal further develops to 4000 cells, it still does not have any visible pigment, but we identified a specific region where the cells were larger than their surrounding neighbours. This was the pre-pattern.”

A computational model developed by Dr Argyris Zardilis provided further insights, and combining both computational models and experimental results, the researchers showed that hibiscus can vary bullseye dimensions very early during the pre-patterning phase or modulate growth in either region of the bullseye, by adjusting cell expansion or division, later in development.

Dr Riglet then compared the relative success of the bullseye patterns in attracting pollinators using artificial flower discs that mimicked the three different bullseye dimensions.

Dr Riglet explained: “The bees not only preferred the medium and larger bullseyes over the small bullseye, they were also 25% quicker visiting these larger flower discs. Foraging requires a lot of energy and so if a bee can visit four flowers rather than three flowers in the same time, then this is beneficial for the bee, and also the flower.”

The findings suggest that these pre-patterning strategies could have deep evolutionary roots, potentially influencing the diversity of flower patterns across different species. The next step for the research team is to identify the signals responsible for generating these early patterns and to explore whether similar pre-patterning mechanisms are used in other plant organs, such as leaves.

This research not only advances our understanding of plant biology but also highlights the intricate connections between plants and their environments, showing how precise natural designs can play a pivotal role in the survival and evolution of species.

For example, H. richardsonii, which has the smallest bullseye of the three hibiscus plants studied in this research, is a critically endangered plant native to New Zealand. H. trionum is also found in New Zealand, but not considered to be native, and is widely distributed across Australia and Europe and has become a weedy naturalised plant in North America. Additional research is needed to determine whether the larger bullseye size helps H. trionum attract more pollinators and enhance its reproductive success.

Patterns on the flowers of plants guide insects, like bees, to the centre of the flower, where nectar and pollen await, enhancing the plant's chances of successful pollination. Despite their importance, surprisingly little is known about how these petal patterns form and how they have evolved into the vast diversity we see today, including spots, stripes, veins, and bullseyes.

These findings pave the way for further research into how petal patterns influence the survival and evolution of flowering plant species.

Reference

Riglet, L. et al: 'Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions'. September 2024, Science Advances. DOI: 10.1126/sciadv.adp5574

Flowers like hibiscus follow an invisible blueprint established very early in petal formation that precisely dictates the size of their central bullseye – a crucial pattern that can significantly impact their ability to attract pollinating bees.

Lucie RigletEdwige MoyroudArgyris ZardilisSainsbury LaboratoryQueens' CollegeSchool of the Biological SciencesWe identified a specific region where the cells were larger than their surrounding neighbours - this was the pre-pattern.Lucie Riglet Bumblebees prefer bigger targets

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The study, by researchers at the University of Cambridge’s Sainsbury Laboratory also found that bees prefer larger bullseyes over smaller ones and fly 25% faster between artificial flower discs with larger bullseyes – potentially boosting efficiency for both bees and blossoms. 

Patterns on the flowers of plants guide insects, like bees, to the centre of the flower, where nectar and pollen await, enhancing the plant's chances of successful pollination. Despite their importance, surprisingly little is known about how these petal patterns form and how they have evolved into the vast diversity we see today, including spots, stripes, veins, and bullseyes. 

Using a small hibiscus plant as a model, researchers compared closely related plants with the same flower size but three differently sized bullseye patterns featuring a dark purple centre surrounded by white – H. richardsonii (small bullseye covering 4% of the flower disc), H. trionum (medium bullseye covering 16%) and a transgenic line (mutation) of H. trionum (large bullseye covering 36%). 

They found that a pre-pattern is set up on the petal surface very early in the flower’s formation long before the petal shows any visible colour. The petal acts like a 'paint-by-numbers' canvas, where different regions are predetermined to develop specific colours and textures long before they start looking different from one another. 

The research also shows plants can precisely control and modify the shape and size of these patterns using multiple mechanisms, with possible implications for plant evolution. By fine-tuning these designs, plants may gain a competitive advantage in the contest to attract pollinators or maybe start attracting different species of insects. 

These findings are published in Science Advances. 

Dr Edwige Moyroud, who leads a research team studying the mechanisms underlying pattern formation in petals, explained: “If a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of tools. By studying how bullseye patterns change, what we are really trying to understand is how nature generates biodiversity.” 

Lead author Dr Lucie Riglet investigated the mechanism behind hibiscus petal patterning by analysing petal development in the three hibiscus flowers that had the same total size but different bullseye patterns. 

3_hibiscus_bullseyes-2-01-01_sml.jpg

She found that the pre-pattern begins as a small, crescent-shaped region long before the bullseye is visible on tiny petals less than 0.2mm in size. 

Dr Riglet said: “At the earliest stage we could dissect, the petals have around 700 cells and are still greenish in colour, with no visible purple pigment and no difference in cell shape or size. When the petal further develops to 4000 cells, it still does not have any visible pigment, but we identified a specific region where the cells were larger than their surrounding neighbours. This is the pre-pattern.” 

These cells are important because they mark the position of the bullseye boundary, the line on the petal where the colour changes from purple to white – without a boundary there is no bullseye! 

A computational model developed by Dr Argyris Zardilis provided further insights, and combining both computational models and experimental results, the researchers showed that hibiscus can vary bullseye dimensions very early during the pre-patterning phase or modulate growth in either region of the bullseye, by adjusting cell expansion or division, later in development. 

Dr Riglet then compared the relative success of the bullseye patterns in attracting pollinators using artificial flower discs that mimicked the three different bullseye dimensions. Dr Riglet explained: “The bees not only preferred the medium and larger bullseyes over the small bullseye, they were also 25% quicker visiting these larger flower discs. Foraging requires a lot of energy and so if a bee can visit 4 flowers rather than 3 flowers in the same time, then this is probably beneficial for the bee, and also the plants.” 

The researchers think that these pre-patterning strategies could have deep evolutionary roots, potentially influencing the diversity of flower patterns across different species. The next step for the research team is to identify the signals responsible for generating these early patterns and to explore whether similar pre-patterning mechanisms are used in other plant organs, such as leaves. 

This research not only advances our understanding of plant biology but also highlights the intricate connections between plants and their environments, showing how precise natural designs can play a pivotal role in the survival and evolution of species. 

For example, H. richardsonii, which has the smallest bullseye of the three hibiscus plants studied in this research, is a critically endangered plant native to New Zealand. H. trionum is also found in New Zealand, but not considered to be native, and is widely distributed across Australia and Europe and has become a weedy naturalised plant in North America. Additional research is needed to determine whether the larger bullseye size helps H. trionum attract more pollinators and enhance its reproductive success. 

Reference 
Lucie Riglet, Argyris Zardilis, Alice L. M. Fairnie, May T. Yeo, Henrik Jönsson and Edwige Moyroud (2024) Hibiscus bullseyes reveal mechanisms controlling petal pattern proportions that influence plant-pollinator interactions. Science Advances. DOI: 10.1126/sciadv.adp5574 

Flowers like hibiscus use an invisible blueprint established very early in petal formation that dictates the size of their bullseyes – a crucial pre-pattern that can significantly impact their ability to attract pollinating bees.  

flowersplantsbeesLucie RigletEdwige MoyroudSainsbury LaboratoryQueens' CollegeSchool of the Biological SciencesIf a trait can be produced by different methods, it gives evolution more options to modify it and create diversity, similar to an artist with a large palette or a builder with an extensive set of toolsEdwige Moyroud Bumblebees prefer bigger targets Lucie RigletArtificial flower discs designed to mimic the bullseye sizes of the three hibiscus flowers

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The technology from Cancer Grand Challenges team IMAXT uses advanced spatial biology techniques to analyse tumours, some of which are based on technology originally developed to map the Milky Way and discover new planets. Now, other scientists will be able to access these technologies to create detailed tumour maps that could one day transform how we diagnose and treat cancer.

Led by Professor Greg Hannon and Dr Dario Bressan at the Cancer Research UK Cambridge Institute and Dr Nicholas Walton at the University of Cambridge’s Institute of Astronomy, SPACE will give other researchers the opportunity to study cancer in a way that wasn’t previously possible.

Dr Dario Bressan, Head of the SPACE Laboratory at the Cancer Research UK Cambridge Institute, said: “Tumours aren’t just a uniform mass of cells; they consist of a diverse ecosystem of cancer cells, immune cells, and other essential components that support their survival. Hidden within these intricate networks lies valuable information which could guide us in making more personalised treatment decisions for each patient. 

“With the SPACE platform, researchers can zoom into specific cell populations, highlight the complex connections between them, and even run virtual experiments to predict how the tumour might respond to different treatments. By unlocking these insights, we can transform the future of cancer care and uncover new opportunities for targeted therapies.” 

The IMAXT team was first awarded £20 million in 2017 by Cancer Research UK through Cancer Grand Challenges, a global research initiative co-founded by Cancer Research UK and the National Cancer Institute in the US.

Since then, the team has united experts from fields rarely brought together including medicine, Virtual Reality (VR), programming, molecular biology, chemistry, mathematics, and even astronomy, to create a completely immersive tool for studying tumours.

As well as enabling scientists to analyse 3D tumour maps, IMAXT created pioneering VR technology which allows the user to ‘step inside’ a tumour using a VR headset.

With the headset, scientists get to view vast amounts of detailed data about individual tumour cells in a 3D space. Instead of looking at this data on a computer screen, they can see all the information in real-time, as if they were inside the tumour itself.

Professor Greg Hannon, Director of the Cancer Research UK Cambridge Institute, said: "Cancer Grand Challenges offers a unique opportunity for international teams to address some of cancer’s biggest challenges. When we took on our particular challenge, much of what we proposed was science fiction.

“Over the past 7 years, our team has turned those early hopes and ideas into approaches that can now be made broadly available. In nature, biology unfolds in three dimensions, and we now finally have the tools to observe it that way—giving us a much deeper, more accurate view of cancer. We’re thrilled to share these breakthroughs with the broader cancer research community."

ioa-space-image_full.jpg

Director of Cancer Grand Challenges at Cancer Research UK, Dr David Scott, said: “IMAXT is changing what’s possible when it comes to cancer research.  

“We can glean important insights about a tumour by analysing its genetic makeup or its proteins, but no technology alone can give us the depth of understanding needed to truly understand this complex disease.  

“By combining state-of-the-art technology and vast expertise, IMAXT will change how cancers are classified, treated and managed, giving more people a better chance of surviving their disease.” 

The funding will support the SPACE hub laboratory, hosted at the CRUK Cambridge Institute, and the SPACE analysis and computing platform, developed and operated at the Institute of Astronomy, University of Cambridge. Together SPACE includes and combines most available technologies for the spatial molecular profiling of tumours. The continued collaboration between the cancer and astronomy teams from the IMAXT project will ensure the maintenance and development of all critical aspects of the platform – from technical and scientific expertise to instrumentation, computing, and data analysis – to allow SPACE to continue at the forefront research in the rapidly emerging spatial-omics field, and be a valuable centre of excellence to support new research in the Cancer Grand Challenge and cancer research communities.

SPACE is funded by Cancer Research UK through Cancer Grand Challenges. Additional support for the SPACE project has been provided by the UK Space Agency through their funding of the development of imaging and analysis techniques at the IoA, Cambridge for a range of space science missions. These have been successfully applied to spatial imaging data through IMAXT and are ready for wider use in SPACE.

Dr Paul Bate, Chief Executive Officer at UK Space Agency said: “Space is powering our daily lives, from satellite navigation to weather forecasts and climate monitoring. This collaboration between the cancer and astronomy teams in the IMAXT project is another real-world example of how space science and technology is bringing benefits to people here on Earth. 

“Thanks to this partnership, the same science and technology that mapped the Milky Way may soon have a positive impact on people battling cancer, and could support doctors to provide better, faster treatment." 

Going forward, a next-generation version of the VR technology will be further developed and commercialised by Suil Vision, a start-up company recently launched by IMAXT team members and Cancer Research UK’s innovation arm, Cancer Research Horizons. Suil Vision is the first start-up to emerge from the Cancer Grand Challenges programme. With a £500,000 investment from the Cancer Research Horizons Seed Fund, Suil Vision will create a market-ready version of their suite of VR technologies for analysing multiple types of biological data, rolling these out across research institutions and companies worldwide. 

Image

Top: Lung with two metastatic lesions derived from a mouse primary triple-negative breast tumour. The figure shows how the registration of the different imaging modalities to a cellular level allow to segment individual cells and identify tumour cell populations, differentiate hypoxic areas, increased fibrosis, infiltration of immune cells and blood and lymphatic vessels by staining with a panel of 35 cell markers at the same time. Bottom: Sample in 3D depicts a tumour grown in the mammary gland of a mouse showing the power of the SPACE pipeline to produce and visualise large volumes (typically ~100,000 individual images registered and stitched and up to 500TB 500 GB of data). The orange fluorescence beads are clearly visible in the medium outside the biological tissue and prove to be crucial for all stages of multimodal registration.

Adapted from a press release by Cancer Research UK

A unique collaboration of astronomers and cancer researchers at Cambridge has been awarded more than £5m to establish the Spatial Profiling and Annotation Centre of Excellence (SPACE) to open up access to their groundbreaking cancer mapping technology and establish collaborations with other scientists to enable them to investigate tumours in 3D.

CancerastronomyDario BressanGreg HannonNicholas WaltonCancer Research UK (CRUK)UK Space AgencySchool of Clinical MedicineSchool of the Physical SciencesCancer Research UK Cambridge InstituteCancer Research UK Cambridge CentreInstitute of AstronomyWhen we took on our particular challenge, much of what we proposed was science fictionGreg HannonSPACE LaboratoryLung with two metastatic lesions derived from a mouse primary triple-negative breast tumour

The text in this work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. Images, including our videos, are Copyright ©University of Cambridge and licensors/contributors as identified. All rights reserved. We make our image and video content available in a number of ways – on our main website under its Terms and conditions, and on a range of channels including social media that permit your use and sharing of our content under their respective Terms.

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