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Available Studentships

PhD Studentship - Copy number signatures in single cells as biomarkers for drug response

From Studentships at the University of Cambridge. Published on Sep 23, 2020.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application. Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study

Dr Florian Markowetz wishes to appoint a student to work on the project entitled: Copy number signatures in single cells as biomarkers for drug response.

For further information about the research group, including their most recent publications, please visit their website: https://www.cruk.cam.ac.uk/research-groups/markowetz-group

Project description: The goal of this project is to overcome the genomic complexity of cancers with high chromosomal instability by using signatures of ongoing mutational processes as biomarkers for drug response. Chromosomal instability is a hallmark of most lethal cancers. Highly unstable tumours have few biomarkers to guide treatment decisions and patient survival has not improved for decades. We have pioneered approaches to dissect chromosomal instability using genome-wide DNA copy number patterns, so called CIN signatures, which are characteristic for different types of instability and underlying mutational processes (Macintyre et al, 2018). We have further developed a novel single cell DNA sequencing approach to identify ongoing mutational processes from unique events in individual cells. This pharmacogenomic test allows us to separate ongoing mutational processes, which are actively contributing to cancer development, from extinct mutational processes, which left marks in the genome but are no longer active. The student will develop a computational framework to use single cell copy number profiles as drug biomarkers and apply it to cell line and organoid data.

Further reading: Copy-number signatures and mutational processes in ovarian carcinoma G. Macintyre et al. Nature Genetics, 50, 1262¿1270 (2018) PMID:30104763 ' doi:10.1038/s41588-018-0179-8 ' bioRxiv:174201

Qualifications/skills: We are seeking to appoint a student with prior experience in genomic data analysis. Applicants must have computer programming skills and be familiar with data analysis in R and Python.

Funding: This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.

Eligibility: No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply: All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following:

Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the 'Research summary' text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the 'Research Supervisor' text box. Please describe your past 'Research experience' in the appropriate text box.

Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results.

Deadline: The closing date for applications is 15 November 2020, with interviews expected to take place in December/January.

Please quote reference SW24178 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship - High-order chromatin structure and oncogenic stress

From Studentships at the University of Cambridge. Published on Sep 23, 2020.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application. Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study

Professor Masashi Narita wishes to appoint a student to work on the project entitled: High-order chromatin structure and oncogenic stress.

For further information about the research group, including their most recent publications, please visit their website: https://www.cruk.cam.ac.uk/research-groups/narita-group

Project description: Low levels of oncogenic RAS promote proliferation, whereas high levels induce senescence. This non-linear effect of RAS on cell proliferation suggests that there is a 'tipping point' for senescence induction. We have recently found that oncogene-induced senescence is accompanied by a drastic rewiring of the enhancer-promoter landscape (BioRxive). We hypothesise that alterations of the dynamic and plastic high-order chromatin structure landscape might determine the oncogenic tipping point. We will address this question, using cell biology and genomic (Hi-C, ChIP-seq etc.) approaches as well as through close collaboration with computational biologists.

Further reading: Transcription-driven cohesin repositioning rewires chromatin loops in cellular senescence Olan I. et al. (https://www.biorxiv.org/content/10.1101/823831v1)

Qualifications/skills: Applicants with experience in genomics methods are particularly encouraged to apply.

Funding: This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.

Eligibility: No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply: All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following:

Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the 'Research summary' text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the 'Research Supervisor' text box. Please describe your past 'Research experience' in the appropriate text box.

Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results

Deadline: The closing date for applications is 15 November 2020, with interviews expected to take place in December/January.

Please quote reference SW24183 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship - Non-invasive imaging of the tumour vascular microenvironment during radiotherapy response

From Studentships at the University of Cambridge. Published on Sep 23, 2020.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application. Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study Professor Sarah Bohndiek wishes to appoint a student to work on the project entitled: Non-invasive imaging of the tumour vascular microenvironment during radiotherapy response.

The mission of the VISIONLab in Cambridge is to advance our understanding of tumour evolution using next-generation imaging sciences. We are particularly interested in using the absorption of light by haemoglobin in blood as a window on disease, using non-invasive imaging to reveal tumour vessel-forming mechanisms and vascular phenotypes. More information about the VISIONLab can be found on our website (www.bohndieklab.org).

Project description Optoacoustic imaging is an emerging clinical technology that combines the high contrast of optical imaging with the spatial resolution of ultrasound (1). Recent work in the VISIONLab has shown that this technology can be used to identify tumour vascular phenotypes and oxygenation status at unprecedented resolution and depth in vivo (2-4). A crucial application for such imaging methods is radiotherapy, where imaging of blood oxygenation and tumour tissue hypoxia finds applications in monitoring response and determining radioresistance.

This PhD project will focus on studying tumour oxygenation and perfusion before, during and after radiotherapy in advanced mouse models. These studies will run in parallel with imaging in patient trials in the clinic, which the student will have an opportunity to support, seeing their efforts transition from bench to bedside. The student will have the opportunity to work across multiple research environments and departments, with potential for research visits to other centres within the CRUK Radiation Research Network and beyond.

References 1. E Brown, J Brunker and S E Bohndiek (2019) Photoacoustic imaging as a tool to probe the tumour microenvironment. Dis Model Mech 12 039636 2. M R Tomaszewski, M Gehrung, J Joseph, I Quiros-Gonzalez, J Disslehorst and S E Bohndiek (2018) Oxygen Enhanced- and Dynamic Contrast Enhanced- Optoacoustic Tomography provide surrogate biomarkers of tumour vascular function, hypoxia and necrosis. Cancer Res 78 (20) 5908-5991. 3. I Quiros-Gonzalez, M R Tomaszewski, S Aitken, L Bollepalli, L McDuffus, M Gill L Hacker, and S E Bohndiek (2018) Optoacoustic delineates murine breast cancer models displaying angiogenesis and vascular mimicry. Br J Cancer 118 1098-1106. 4. M R Tomaszewski, I Quiros-Gonzalez, J O'Connor, O Abeyakoon, G Parker, K Williams, F Gilbert and S E Bohndiek (2017) Oxygen enhanced photoacoustic imaging reveals vascular dynamics in murine models of prostate cancer. Theranostics 7 (11) 2900-2915.

Desirable qualifications and skills: We are seeking a PhD candidate with a 1st class honours degree (held or predicted) in biological or biomedical sciences. We strongly value a candidate with the desire to learn, create and innovate. The project will combine a majority of experimental imaging with a minority computational element for image analysis and statistics. Full training will be provided in both areas. The successful candidate should have a strong interest in cancer biology. Additional relevant skills include: excellent oral and written communication skills; strong team working skills; an ability to take initiative to solve problems; strong motivation in driving projects forward; and a significant critical thinking capability. Examples of any past experience that demonstrates these characteristics should be highlighted in the cover letter that accompanies any application. We expect the candidate will develop into an independent experimental researcher and will present their work in academic journals, as well as at conferences.
Candidates with previous experience of in vivo imaging, for example during a Masters or Diploma degree, are particularly encouraged to apply.

Funding: Cancer Research UK has joined with the universities of Cambridge, Glasgow, Leeds, Manchester and Oxford, the CRUK City of London Centre and the Institute of Cancer Research in partnership with the Royal Marsden NHS Foundation Trust, London to create a network of centres of excellence in radiation research, CRUK RadNet. This PhD project is funded through the CRUK RadNet award to the University of Cambridge and includes full funding for University and College fees and a stipend of £19,000 per annum.

Eligibility: Only Home/UK students are eligible to apply for this studentship.

Further information: This funded PhD project will be based in the Cancer Research UK Cambridge Institute at the University of Cambridge. Requests for more information about the project or questions related to candidate experience should be made to Professor Sarah Bohndiek (seb53@cam.ac.uk) with the subject line "Optoacoustic PhD 2021" before the application to the University is complete.

How to apply: All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following:

Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the 'Research summary' text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the 'Research Supervisor' text box. Please describe your past 'Research experience' in the appropriate text box.

Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results

Deadline: The closing date for applications is 15 November 2020, with interviews expected to take place in December/January.

Please quote reference SW24184 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentship - The molecular mechanisms of piRNA-guided transposon silencing

From Studentships at the University of Cambridge. Published on Sep 23, 2020.

The Cancer Research UK Cambridge Institute (CRUK CI) is a joint venture between the Charity, Cancer Research UK, and the University of Cambridge. The Institute has excellent state-of-the-art facilities and research ranges from basic cancer biology and computational biology through to translational research and clinical application. Graduate students play a pivotal role in the continuing success of our research programmes and gaining a studentship in the Institute is an excellent opportunity to start a research career in an environment committed to training outstanding cancer research scientists of the future. For further information, go to: https://www.cruk.cam.ac.uk/jobs-and-studentships/postgraduate-study

Professor Greg Hannon and Dr Benjamin Czech wish to appoint a student to work on the project entitled: The molecular mechanisms of piRNA-guided transposon silencing.

For further information about the research group, including their most recent publications, please visit their website: https://www.cruk.cam.ac.uk/research-groups/hannon-group

Project description: The Hannon laboratory has a long-standing interest in small RNA biology. In recent years, the lab has focused on the study of the PIWI-interacting RNAs (piRNAs) in Drosophila melanogaster. The piRNA pathway is an RNA-based immune system that protects the germline of animals from uncontrolled transposon mobilisation, thus safeguarding genome integrity. Our lab has pioneered this field, being amongst the first describing the pathway, carrying out large-scale genomic screens to identify the main players and characterising their role within the pathway.

This project aims to uncover the molecular mechanisms that underlie the piRNA pathway using the fruit fly Drosophila melanogaster as a model. While a rough framework of the piRNA system has been established, the precise hierarchy of the events that result in silencing is not yet fully understood. This aim will be achieved by combining biochemistry, proteomics, cell biology, genomics (RNA-seq, small RNA-seq, CLIP-seq, ChIP-seq), imaging and bioinformatics and by exploiting in vitro cell culture models as well as fly genetics. Overall, this project will lie at the interface between small RNA-mediated silencing, chromatin biology and development.

Further reading: 1. Czech B, et al. (2018). piRNA-Guided Genome Defense: From Biogenesis to Silencing. Annual Review of Genetics. 2. Munafò M, et al. (2019). Daedalus and Gasz recruit Armitage to mitochondria, bringing piRNA precursors to the biogenesis machinery. Genes & Development. 3. Fabry MH, et al. (2019). piRNA-guided co-transcriptional silencing coopts nuclear export factors. eLife. 4. Kneuss E, et al. (2019). Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export. Genes & Development.

Qualifications/skills: The ideal candidate would have a relevant undergraduate degree, a keen interest in working on this project, and would be highly motivated to drive an independent research project. A research Master's degree with six months or more of lab experience, as well as a strong background in genetics, biochemistry or cell/molecular biology would be highly desirable. The successful candidate is expected to work closely with other team members, have excellent communication skills and record keeping habits, organisational and time-management skills, and an inquisitive mind.

Funding: This project is funded by a Cancer Research UK studentship that includes full funding for University and College fees and a stipend of £19,000 per annum.

Eligibility: No nationality restrictions apply to Cancer Research UK funded studentships. Applications are invited from recent graduates or final year undergraduates who hold or expect to gain a first/upper second class degree (or equivalent) in a relevant subject from any recognised university worldwide.

How to apply: All applications need to be made using the University Applicant Portal. Please visit: https://www.graduate.study.cam.ac.uk/courses/directory/cvcrpdmsc for further information about the course and to access the applicant portal.

To complete your on-line application, you need to provide the following:

Reference Request: The names and contact details of two academic referees who have agreed to act on your behalf.

Research: If you wish to be considered for more than one studentship, please enter the names of all of the supervisors you wish to consider your application in the 'Research summary' text box. If you only wish your application to be considered by a single supervisor, then please enter their name in the 'Research Supervisor' text box. Please describe your past 'Research experience' in the appropriate text box.

Course Specific Questions: Your statement of interest (limit of 2,500 characters) should explain why you wish to be considered for the studentship and which qualities and experience you will bring to the role. Please also state how you learned of the studentship.

Supporting Documents: Please upload your CV (PDF file), which should include a list of the examinations taken at undergraduate level and if possible, your examination results

Deadline: The closing date for applications is 15 November 2020, with interviews expected to take place in December/January.

Please quote reference SW24181 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

PhD Studentships in crop molecular genetics

From Studentships at the University of Cambridge. Published on Sep 21, 2020.

Applications are invited for 4 year PhD studentships in crop molecular genetics to work with Profs Uta Paszkowski and Giles Oldroyd at the Crop Science Centre as part of the Engineering the Nitrogen Symbiosis for Africa Project (ENSA: https://www.ensa.ac.uk).

The research projects focus on the mechanisms by which plants regulate beneficial symbioses in cereals. The projects will continue ongoing efforts to understand the integration of permissive and non-permissive fertilizer conditions on symbiosis development and across cereal root types (Gutjahr et al., PNAS 2015). The projects use molecular genetics, physiology and cell biological approaches. The successful applicants should have a background in plant biology.

Interested candidates should first make informal enquiries about this post to Prof Uta Paszkowski up220@cam.ac.uk before 31st October.

These studentships provide up to 4 years maintenance and tuition fees at the standard UKRI rate. They are open to UK citizens or international students who meet the UK residency requirements or are able to augment the funds to cover the extra costs associated with international student fees.

To apply for this studentship, candidates must apply through the University's Graduate Admissions application portal not later than 14 January for an Easter 2021 start or 30th June for a Michaelmas 2021 start. The portal is at: https://www.postgraduate.study.cam.ac.uk/courses/directory/blpspdpsc and there is a £70 fee for PhD applications.

One appointment will be known as The Trinity Cawthorn PhD Studentship in Crop Sciences. To be considered for this an application must also be made by 8th Jan for a Michaelmas 2021 start via https://www.trin.cam.ac.uk/postgraduate/graduate-funding-awards/

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Senior Clinical Training Scholarship (SCTS) in Diagnostic Imaging

From Studentships at the University of Cambridge. Published on Sep 14, 2020.

SCHOLARSHIP AWARD £23,600.00 IN YEAR 1 (TAX FREE)

This Senior Clinical Training Scholarship (SCTS) provides an outstanding opportunity to study for a postgraduate qualification, and is available to start on 1 November 2020 or as soon as possible thereafter. You will be trained in all aspects of veterinary diagnostic imaging, including radiology, ultrasonography, magnetic resonance imaging and computed tomography. The training programme is approved by the European College of Veterinary Diagnostic Imaging.

The Scholarship is for one year in the first instance, renewable for periods of one year up to a total of three years. It is subject to an initial monitoring period of six months and review on an annual basis.

You will be required to register with the ECVDI for the Diploma in Diagnostic Imaging. The training programme requires participation in the Department's clinical service, including the out-of-hours rota and first opinion clinic, in addition to small-group teaching of veterinary students. You will also be expected to participate in research projects as part of your training.

You must be a Member of the Royal College of Veterinary Surgeons, or hold a veterinary degree qualifying you for membership. Completion of a recognised internship or a minimum of two years' experience in small animal practice is essential.

Informal enquiries should be directed to Helen Boyle, HR Co-ordinator, by email: hmab3@cam.ac.uk

We welcome candidates wishing to apply for the scholarship to come and visit the hospital and to meet the team, however a visit will need to be organised in accordance with the restrictions due to the ongoing Covid-19 pandemic. Please contact Marie-Aude Genain, Principal Clinical Radiologist, on mag72@cam.ac.uk to arrange a convenient date.

A SCTS application form (SCTS1) and information pack can be downloaded from the following website: https://www.vet.cam.ac.uk/job

Applicants should supply a completed SCTS Application Form (SCTS1), Curriculum Vitae and Covering Letter giving reasons for wishing to undertake the SCTS in the Department of Veterinary Medicine, University of Cambridge.

Applications should be submitted via e-mail to vetmed@hermes.cam.ac.uk with the above documents as one attachment, by the closing date stated.

Interviews will be held on Friday 30 October 2020.

Please quote reference PP24080 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.